We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Primitive Genetic Alphabet Based on RNA and DNA
News

Primitive Genetic Alphabet Based on RNA and DNA

Primitive Genetic Alphabet Based on RNA and DNA
News

Primitive Genetic Alphabet Based on RNA and DNA

Credit: Pixabay
Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Primitive Genetic Alphabet Based on RNA and DNA"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

The origin of life and the nature of the first genetic polymer is the subject of major debate. One of the theories – the RNA world theory – suggests that RNA was the first replicable information carrier at the dawn of life whereas other evidence implies that life may have started with a heterogeneous nucleic acid genetic system comprising mixed RNA and DNA. The latest research from LMB scientists supports the latter idea.

LMB scientists Jianfeng Xu, Václav Chmela, Nicholas Green, and David Russell from John Sutherland’s Group and others, including theoreticians led by Rafal Szabla at Edinburgh University, conclude that reasonable amounts of the building blocks of such a heterogenous genetic material may have been available on primordial Earth.

Starting with a mixed RNA-DNA nucleic acid streamlines the eventual ‘genetic takeover’ of homogeneous DNA from RNA as the principal information storage molecule in the central dogma, but requires a selective abiotic synthesis of both RNA and DNA building blocks in the same local primordial geochemical scenario. The central dogma, which was proposed by Francis Crick, emphasizes that the flow of genetic information from the nucleic acids, DNA and RNA, to make proteins is a one way process.

Purines and pyrimidines are the two different kinds of nucleobases in DNA and RNA. Adenine (A) and guanine (G) are purines and cytosine (C), thymine (T) and uracil (U) are pyrimidines. Purine-pyrimidine base pairs (A with U or T and C with G) are key to information transfer. Ribonucleosides have a nucleobase attached to the sugar ribose whereas in deoxyribonucleosides the sugar is deoxyribose.

The researchers demonstrated a high-yielding, completely stereo-, regio-, and furanosyl-selective prebiotic synthesis of the purine deoxyribonucleosides, deoxyadenosine and deoxyinosine. Deoxyadenosine is one of the naturally occurring, or canonical purine deoxyribonucleosides, deoxyinosine is not but is thought to be able to take the place of the canonical deoxyguanosine.

Their synthesis utilized key intermediates in the prebiotic synthesis of the pyrimidine ribonucleosides, cytidine and uridine. The paper shows that, once generated, the pyrimidine ribonucleosides persist throughout the synthesis of the purine deoxyribonucleosides suggesting that two DNA building blocks may have coexisted with two base pairing RNA partners at the dawn of life.

John, who is a group leader in the PNAC Division, explains, “The nucleic acids, RNA and DNA are clearly related and this work suggests that they both derive from a hybrid ancestor rather than one preceding the other. Guided by Crick’s central dogma, we now need to uncover how the sequential information which can be stored and purveyed by these nucleic acids was first transferred to proteins.”

Reference

Xu et al. (2020). Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides. Nature. DOI: https://doi.org/10.1038/s41586-020-2330-9

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Advertisement