ProNAi and Novosom Announce Collaboration to Deliver DNAi®-Based Cancer Therapeutics
News Mar 07, 2007
ProNAi Therapeutics, Inc. has announced collaboration with Novosom AG to enable successful delivery of DNAi®-based cancer therapeutics.
Under the terms of the collaboration, ProNAi will license Novosom’s SMARTICLES® liposome technology for use in all human disease targeted by ProNAi’s PNT100 drug candidate. The agreement comprises an upfront payment, milestone payments and royalties, composed of a mixture of cash and equity. ProNAi will also retain an option for four additional DNAi® targets.
Dr. Richard D. Gill, President and CEO of ProNAi, said, “Team ProNAi is very much looking forward to realizing the results of our collaboration with Novosom in this groundbreaking endeavor, as we bring the drug product PNT2258 to IND submission. The successful delivery of nucleic acid-based drugs has been the ‘holy grail’ of the industry for many years, and we are confident that our combined approach will yield promising outcomes.”
Gill continued, “With this partnership, we have developed a GMP-enabling oligo delivery method that allows ProNAi to submit an IND, and we expect more significant milestones to be met in the near future.”
Elias Papatheodorou, CEO of Novosom, said, “Novosom’s technology has been in the forefront of providing a safer, more efficient delivery method available for in vivo delivery of nucleotides to targeted cells. We are encouraged by the potential our partnership with ProNAi holds in developing a new class of effective DNA-based drugs.”
As genome editing technologies advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. However, challenges need to be addressed before potential treatments can be widely used in patients. To tackle these challenges, the National Institutes of Health has launched the Somatic Cell Genome Editing program, which has awarded multiple grants including more than $3.6 million to assess the safety of genome editing in human cells and tissues.