ReNeuron Announces Research Collaboration with Benitec Biopharma
News Jun 23, 2015
ReNeuron Group plc has announced the extension of an ongoing research collaboration with Australia-based Benitec Biopharma following positive results in early studies.
Researchers at ReNeuron and Benitec have discovered that ReNeuron’s CTX-derived exosomes are potentially an effective delivery system for Benitec’s proprietary ddRNAi gene silencing technology, resulting in the silencing of specific genes in recipient cells to beneficial therapeutic effect.
These early studies also indicate that ReNeuron’s CTX stem cells are a more effective producer cell type for this purpose than mesenchymal cells, a widely used cell type against disease targets in stem cell therapy. Following these exploratory studies, ReNeuron is extending its research collaboration with Benitec in order to further test the potential of this combination technology approach, targeting lung cancer and other drug resistant cancers.
ReNeuron is a first-mover in the field of exosome-based therapeutics and has filed multiple patent applications covering the composition, manufacture and therapeutic use of its exosome nanomedicine platform. Exosomes are nanoparticles secreted from all cells and which are believed to play a key role in the transfer of beneficial proteins and particularly non-coding RNAs from one cell to another. ReNeuron aims to exploit the therapeutic potential of exosomes derived from its own proprietary stem cell lines.
Dr Peter French, Chief Executive Officer of Benitec, commented: “We are delighted to be working with ReNeuron in this exciting emerging field of gene- and cell-based therapeutics. The application of Benitec’s ddRNAi technology to ReNeuron’s stem cell and exosome platforms represents a unique technology combination and opens up a wide array of possibilities for extending both companies’ core platforms into new therapeutic areas. Having ReNeuron as a collaborator on this approach increases the chances of success as their knowledge of stem cell science coupled with their unique technology platforms are tremendous assets in this area.”
Olav Hellebø, Chief Executive Officer of ReNeuron, commented: “We are increasingly excited by the potential of our exosome platform, most particularly as a potential new therapeutic approach targeting cancer. The early data we have generated indicates that our CTX-derived exosomes may become a valuable new pipeline of cancer therapeutic candidates. We are also delighted to be extending our research collaboration with Benitec to explore the potential of our exosomes as a delivery system for Benitec’s unique gene silencing technology targeting drug resistant cancers.”
Analytical Tool Predicts Disease-Causing GenesNews
Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function, is now possible thanks to an international team of researchers that has developed a new analytical tool to effectively and efficiently predict such candidate genes.
Single Gene Change in Gut Bacteria Alters Host MetabolismNews
Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice. The research provides an important step towards understanding how the microbiome – the bacteria that live in our body – affects metabolism.READ MORE
High Fruit and Veg Consumption May Reduce Breast Cancer RiskNews
Women who eat a high amount of fruits and vegetables each day may have a lower risk of breast cancer, especially of aggressive tumors, than those who eat fewer fruits and vegetables, according to a new study led by researchers from Harvard T.H. Chan School of Public Health.READ MORE