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Research Newsletter for Biochip User Community


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Fluidigm Corporation has announced that the Fall 2010 edition of its community newsletter is now available free to download from www.fluidigm.com/newsletters/Q3%20newsletter-rev2-FINAL.html.

The Fluidigm Community Newsletter is a quarterly publication dedicated to providing users with the most recent research, product updates, and news featuring Fluidigm Integrated Fluidic Circuit (IFC) technology. Each issue is dedicated to providing new information of interest including new products, applications and customer advances to researchers involved with gene expression, SNP genotyping and sample preparation for next generation sequencing.

In the Fall 2010 issue researchers from the Molecular & Cell Biology Group at LGC (Teddington, UK) describe their investigation into the applicability of using digital PCR to estimate absolute limits of detection and quantitation associated with the validation of traditional real-time PCR methods for analysis of genetically modified (GM) ingredients.

A paper from the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University describes how the Fluidigm BioMark™ system was used to conduct single-cell gene expression analysis identifying factors important to oocyte maturation and using these findings to develop an improved culture system for the in-vitro maturation of cumulus-free oocytes.

A poster from the National Cancer Institute (Frederick, MD, USA) describes how they have accelerated their sample preparation to take full advantage of the high-throughput sequencing capacity from their next-generation sequencers. NCI researchers used the Fluidigm Access Array™ system to amplify and tag, in parallel, 48 unique exons from two cancer-related genes in 60 cancer cell lines. The amplicons were pooled and sequenced, identifying 6 mutations and a SNP from this high-throughput screen. This research raises the potential for large-scale screens to identify mutations associated with cancer.

Complimenting the independent customer research publications the Fall 2010 newsletter also provides abstracts describing, and providing links to, the latest application notes, new product introductions, company news, events program and educational webinars from Fluidigm.
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