We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

RNA Defense System Protects the Genome When it's Epigenetically Naked

News   Jul 03, 2017 | Original story from CSHL

 
RNA Defense System Protects the Genome When it's Epigenetically Naked

A transfer RNA (tRNA) molecule. Fragments of 18 and 22 nucleotides, snipped from a full-length tRNA in the region circled in red, act to defend the genome in embryonic cells in the interval before the young embryo is implanted in the mammalian uterus. The sequences are complementary to, and act to interfere with, a binding site called the PBS in retrotransposons that must be engaged for their activation. About 42% of the human genome consists of parasitic retrotransposon sequences, which epigenetic marks repress except during brief intervals of epigenetic reprogramming. This defense mechanism seems to be analogous to the piRNA defense system that protects the genome in germline cells. Image courtesy of Wikimedia Commons.

 
 
 

RELATED ARTICLES

For the First Time, Astronauts Edit Genes in Space

News

For the first time, astronauts have used CRISPR/Cas9 technology to edit DNA in space. The gene editing technique was deployed on the International Space Station (ISS) to induce targeted breaks in the yeast genome.

READ MORE

Animal Study Cautions Against Overeating Omega-6 Fats in Pregnancy

News

In Western societies, we are eating more omega 6 fats. A research study using rat models showed that eating a diet with three times the recommended daily intake of linoleic acid might be harmful in pregnancy.

READ MORE

Flawed Genome for Widely Researched Worm Is Corrected

News

A new study finds that the genome for a widely researched worm, on which countless studies are based, was flawed. Now, a fresh genome sequence will set the record straight and improve the accuracy of future research.

READ MORE

 

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE