Roche NimbleGen and Baylor College Develop an Improved Version of Sequence Capture 385K Arrays
News Nov 05, 2008
Roche NimbleGen in cooperation with the Human Genome Sequencing Center at Baylor College of Medicine in Houston, Texas has launched an improved version of their Sequence Capture 385K Arrays, the groundbreaking technology for enriching targeted genomic regions for high-throughput sequencing.
The new and improved microarrays allow researchers to perform their own capture experiment and perform quick sequencing of enriched regions using next-generation technology such as the Genome Sequencer FLX System from 454 Life Sciences.
The entire workflow, starting from genomic DNA, to enriched DNA of target regions, and sequencing results takes about two weeks, compared to months or years for traditional PCR-based methods coupled with capillary sequencing. These second version microarrays will also be available through Roche NimbleGen´s Sequence Capture Service.
A critical performance measurement for enrichment technologies is to capture all the target regions with equal efficiency. NimbleGen second generation Sequence Capture Arrays deliver improved performance regarding the specificity and uniformity of captured regions.
Synthetic DNA Shuffling Enzyme Outpaces Natural CounterpartNews
A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitudeREAD MORE
Antarctic Worm and Machine Learning Help Identify Cerebral Palsy EarlierNews
A research team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients. The technique which makes use of machine learning, data science and even analysis of Antarctic worms, raises hopes for earlier targeted CP therapies.
Ancient Syphilis Genomes Decoded for First TimeNews
Researchers recovered three genomes of the bacterium Treponema pallidum from skeletal remains from colonial-era Mexico, and were able to distinguish the subspecies that causes syphilis from the subspecies that causes yaws. It was not previously thought possible to recover DNA from this bacterium from ancient samples.