Scientists Publish Results on Sigma-Aldrich's shRNA Library in Cell
News Apr 13, 2006
The publication reported the creation of a lentiviral shRNA library to knock down genes for genome-wide screening.
The library, now commercially available as Sigma-Aldrich's lentiviral MISSION™ shRNA library, targets 19,000 human and mouse genes and offers a new resource for somatic cell genetics providing new insights in loss-of- function screens in mammalian cells.
It will facilitate comprehensive screening efforts and will be useful in enabling arrayed screens that focus on mouse or human primary cells.
In recent years, numerous studies have shown that people who don't get enough sleep are at greater risk of stroke and heart attack. A study found that people who sleep fewer than 7 hours per night have lower blood levels of three physiological regulators, or microRNAs, which influence gene expression and play a key role in maintaining vascular health.