Scientists Publish Results on Sigma-Aldrich's shRNA Library in Cell

Sigma-Aldrich has welcomed publication in the journal Cell (March 24, 2006) by researchers from its collaborative partners at The RNAi Consortium (TRC).

The publication reported the creation of a lentiviral shRNA library to knock down genes for genome-wide screening.

The library, now commercially available as Sigma-Aldrich's lentiviral MISSION™ shRNA library, targets 19,000 human and mouse genes and offers a new resource for somatic cell genetics providing new insights in loss-of- function screens in mammalian cells.

It will facilitate comprehensive screening efforts and will be useful in enabling arrayed screens that focus on mouse or human primary cells.