Significant Technological Challenges Remain for the Development of RNA-Based Therapeutics
News Feb 07, 2006
Research and Markets has announced the addition of Progress in RNA-Based Therapeutics to their offering.
The field of nucleic acid-based therapeutics ranges from gene therapy technologies for replacing defective or missing genes to gene-blocking or gene-silencing technologies for preventing the expression of deleterious genes.
RNA-based therapeutics are a relatively new addition to the field, and this report focuses on three such technologies in this report: antisense oligonucleotides, RNA interference, and microRNAs.
In this Decision Resources report, these three RNA-based technologies are described, recent progress in RNA-based drug discovery and development is reviewed, and the activities of companies in the field are profiled.
RNA-based technologies include antisense oligonucleotides, RNA interference, and microRNA. Companies have been testing ASOs in the clinic for ten years, and one antisense product, fomivirsen (Isis Pharmaceuticals' Vitravene), is on the market.
Analytical Tool Predicts Disease-Causing GenesNews
Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function, is now possible thanks to an international team of researchers that has developed a new analytical tool to effectively and efficiently predict such candidate genes.
Gene Regulator May Contribute to Protein Pileup in Exfoliation GlaucomaNews
Researchers are seeking factors that contribute to protein pileup in exfoliation glaucomaREAD MORE
Single Gene Change in Gut Bacteria Alters Host MetabolismNews
Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice. The research provides an important step towards understanding how the microbiome – the bacteria that live in our body – affects metabolism.READ MORE