Silicon Biosystems Menarini will develop new workflows focused on translational research that combines its DEPArray™ System with Swift Biosciences’ Next Generation Sequencing (NGS) technology. The announcement was made at the annual Advances in Genome Biology and Technology (AGBT) meeting held in Orlando, February 10th-13th. Both companies will present recent findings of their collaborative research on February 13th.
Tim Harkins, CEO of Swift Biosciences, explained how the combination of the two technologies enables oncology researchers to fully access genomic information locked within formalin-fixed paraffin-embedded (FFPE) tissue samples. “Working with Silicon Biosystems Menarini has revolutionized the analysis of FFPE samples by enabling researchers to perform whole genome, exome and targeted resequencing from samples that previously could not be sequenced. There is a treasure trove of genetic information in countless FFPE collections that can now be unlocked with the combination of these technologies. It is a very exciting time for the oncology community.”
Giuseppe Giorgini, CEO of Silicon Biosystems Menarini added, “Offering our DEPArray system owners the simple and optimized sequencing solution that Swift Biosciences provides will guarantee them reliable and high-quality results that translational research requires.”
Combining the Power of Precise Single-Cell Isolation with NGS
The DEPArray system is capable of isolating a few hundred matched tumor and normal cells from FFPE materials, or from frozen tumor specimens, and cell cultures. Based on the principle of dielectrophoresis, which exploits the ability of a non-uniform electric field to move cells in a spatial gradient, the system provides precise image-based cell selection for identification and sorting of individual cells, or pools of cells, at 100% purity for further genetic analysis or culturing. With Swift Biosciences’ Accel-NGS® 2S DNA Library Kits researchers are able to build complex libraries from as little as 100 pg of DNA. The new Accel-NGS 2S Hyb DNA Library Kit will allow the sequencing of whole exomes from FFPE samples that contain low amounts of damaged and fragmented DNA. The DEPArray System and Accel-Amplicon™ panels have also been optimized together to deliver somatic mutation detection in 56 clinically relevant oncology-related genes.