Sirna Announces Research Alliance with GSK
News May 05, 2006
Sirna Therapeutics, Inc. has announced that as part of its exclusive, multi-year collaboration with GlaxoSmithKline (GSK) in respiratory diseases, the companies have initiated programs in asthma and respiratory syncytial virus (RSV).
As part of the respiratory collaboration, the companies also plan to pursue RNAi-based therapeutics against chronic obstructive pulmonary disease (COPD) and allergic rhinitis.
Sirna will provide GSK with optimized and formulated siRNAs against targets for these diseases and GSK will assume all responsibility for the further preclinical and clinical development of compounds that emerge from these programs.
Sirna designs and develops short interfering RNA compounds which down regulate the expression of critical proteins responsible for viral replication and pathogenesis.
Sirna claims that, local delivery of siRNA to the respiratory tract will substantially enhance the feasibility of developing treatments with this exciting platform technology.
"Sirna has demonstrated the ability to develop chemically modified and optimized siRNA compounds and then deliver those compounds effectively into the lung with our nanoparticle formulations," stated Barry Polisky, PhD, Chief Scientific Officer at Sirna.
"Further, we have demonstrated that our proprietary approach to targeting the conserved region of a viral genome has resulted in significant viral knockdown in a non-human primate model."
"With these encouraging results and together with the combined efforts of Sirna and GSK scientific teams, we expect to expedite the development of novel RNAi-based therapies - those efforts initially focused on asthma and RSV."
In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.