Sloning and Stanford University Start Evaluation Project Regarding the Synthesis of a Statistically Randomized Gene Library
News Apr 25, 2008
Sloning BioTechnology and Roger Kornberg’s group at Stanford University are working on a project to synthesize a gene mutant library where selected codons are introduced in a statistically expected and controlled ratio at preselected positions within a given DNA sequence.
Sloning will utilize its core technology, Slonomics™, a DNA engineering platform using defined sets of double stranded DNA triplets to generate this highly sophisticated kind of gene mutant library.
The group of Dr. Roger Kornberg (Nobel Prize Laureate in Chemistry 2006) at Stanford University will perform in vivo screens based on the library provided by Sloning to identify relevant mutants of a S. cerevisiae RNA Polymerase II.
Jan Van den Brulle, Scientific Director at Sloning commented, “We are looking forward to work together with Dr. Kornberg’s group. This project gives us again the opportunity to demonstrate the power of our technology”.
Dr. Kornberg stated, "This mutant library will allow us to dissect and better understand the transcription mechanism."
GlaxoSmithKline plc (GSK) has launched a five-year, $67 million collaboration with the San Francisco and Berkeley campuses of the University of California to build a state-of-the-art laboratory. The goal is to use CRISPR technologies to explore how genes cause disease and to rapidly accelerate the discovery of new drugs.