SomaGenics Secures NIH Funding
News Oct 05, 2016
SomaGenics has been awarded a $1.8M two-year NIH SBIR Phase II grant to further develop its RealSeq–AC technology for next-generation sequencing (NGS) of small RNAs such as microRNA.
Real-Seq®-AC dramatically reduces bias in small RNA sequencing libraries compared to commercially available library construction methods. “Bias reduction is critical for the discovery of previously undetected RNAs and enables a more accurate analysis of small RNA abundances,” according to Dr. Sergei Kazakov, VP of Discovery Research at SomaGenics and Principal Investigator on the NIH grant.
This Phase II award allows SomaGenics to further develop the RealSeq-AC library construction approach including streamlining the workflow, increasing library yield, and broadening its utility beyond sequencing microRNAs to include other RNA species such tRNAs, fragments of mRNAs and long noncoding RNAs (lncRNAs).
“This additional funding will allow us to continue expanding and optimizing the RealSeq platform, further strengthening SomaGenics’ suite of tools for small RNA discovery and validation. Besides RealSeq, these tools also include our proprietary RT-qPCR technologies miR-ID and miR-Direct, which can be used to validate potential biomarkers discovered through sequencing”, commented Dr. Brian Johnston, CEO of SomaGenics.
Mechanism Controlling Multiple Sclerosis Risk IdentifiedNews
Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism.
Antarctic Worm and Machine Learning Help Identify Cerebral Palsy EarlierNews
A research team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients. The technique which makes use of machine learning, data science and even analysis of Antarctic worms, raises hopes for earlier targeted CP therapies.
Ancient Syphilis Genomes Decoded for First TimeNews
Researchers recovered three genomes of the bacterium Treponema pallidum from skeletal remains from colonial-era Mexico, and were able to distinguish the subspecies that causes syphilis from the subspecies that causes yaws. It was not previously thought possible to recover DNA from this bacterium from ancient samples.