The Epigenome Differentiates the Different Human Populations
News Aug 05, 2013
For years we know that there are genetic differences among different human populations that contribute to their appearance and to a different susceptibility to disease.
These small genetic differences between healthy individuals are called "polymorphisms". The group of Manel Esteller, director of the Programme of Epigenetics and Cancer Biology at the Institute for Biomedical Research of Bellvitge, ICREA researcher and professor of genetics at the University of Barcelona, described today in the prestigious international biomedical journal Genome Research the existence of epigenetic differences between different human populations. That is to say, we are not only different by our DNA (genome) but also by the different regulation of this DNA (epigenome).
"We have studied the epigenomes of three hundred healthy individuals of three large human populations (United States Caucasians, Asians of the chinese ethnic group Han and sub-Saharan Africans) and we have found epigenetic differences that allows us to identify each group of humans"- explains Manel Esteller -"There are genes that are more or less active (due to different levels of the epigenetic mark called DNA methylation) according to the studied population group.
The target genes of these differences between humans are found in all the cellular pathways, but it is worth noting those related with the pigmentation of the skin and the different resistance to infections due to various pathogenic microorganisms, such as the virus (Hepatitis B and HIV) and bacteria (Escherichia coli and Shigella).
This latter finding would help to explain the different tendency to develop a disease among people of different geographic origin."
The discovery has important implications for explaining the richness and diversity of the different human populations that can no longer be attributed only to a different genome, but also to a different epigenome. The speed and reversability of the epigenetic changes in the genome could also explain how occur the necessary changes in our cells and tissues when populations migrate from one territory to another. In evolutionary terms it provides clues to understand the rapid adaptation to the environment of the first humans who dispersed from the Horn of Africa all over the planet.
Edith Heard Unanimously Selected as Next Director General of EMBLNews
At its 53rd meeting yesterday, EMBL Council selected Edith Heard as the organization’s fifth Director General. Heard’s mandate is scheduled to begin 1 January 2019.READ MORE
CRISPR Transforms Living Cells Into Data Storage DevicesNews
Genome engineering technology transforms living cells into archival data storage devices that capture, store, and propagate information over time.READ MORE
Comments | 0 ADD COMMENT
EMBL Course: Next Generation Sequencing: RNA Sequencing Library Preparation
Apr 23 - Apr 27, 2018
EMBO Practical Course: Microbial Metagenomics: A 360º Approach
Apr 23 - Apr 30, 2018
EMBL Course: Next Generation Sequencing: Whole Genome Sequencing Library Preparation
Apr 16 - Apr 20, 2018
EMBL Course: Introduction to Next Generation Sequencing
Apr 09 - Apr 12, 2018