The Living Microarray: a High-Throughput Platform for Measuring Transcription Dynamics in Single Cells
News Feb 21, 2011
The work reported within this article suggests that methods that measure average cellular responses, such as DNA microarrays, RT-PCR and chromatin immunoprecipitation, characterize a response skewed by a subset of cells in the population. The method presented in this paper is scalable and readily adaptable to studying complex systems, including cell proliferation, differentiation and apoptosis.
The article is published online within the journal, BMC Genomics and is free to access.