The Next Phase of Life-Sciences Spaceflight Research: Harnessing the Power of Functional Genomics
News Apr 02, 2012
Spaceflight appears to induce metabolic changes in all species yet studied, many of which are suggested to have detrimental consequences for crew health and performance. These (mal)adaptations represent a major obstacle preventing the worlds’ space agencies from safely achieving their common goal of sending humans on long duration deep-space exploratory missions, and ultimately the human habitation of other planetary bodies. To overcome this obstacle we must first understand the molecular mechanisms regulating spaceflight-induced alterations and, second, utilize this knowledge to effectively target efforts to develop therapeutic strategies.
This article is published online in Communicative and Integrative Biology and is free to access.
In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.