Mutations in the Wnt/ß-catenin pathway occur in most colorectal cancers (CRCs) and these mutations lead to increased nuclear accumulation of the ß-catenin transcriptional co-activator. In the nucleus, ß-catenin associates with TCF/LEF sequence specific transcription factors to activate target gene expression. The Hippo pathway restricts cellular growth by preventing nuclear accumulation of the Yes-associated protein (YAP) transcriptional co-activator. YAP expression is elevated in CRCs suggesting that, like Wnt/ß-catenin signaling, the Hippo pathway may contribute to colorectal carcinogenesis.
This paper was published online in The Journal of Biological Chemistry and is free to access.