Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
News Feb 23, 2012
Mutations in the Wnt/ß-catenin pathway occur in most colorectal cancers (CRCs) and these mutations lead to increased nuclear accumulation of the ß-catenin transcriptional co-activator. In the nucleus, ß-catenin associates with TCF/LEF sequence specific transcription factors to activate target gene expression. The Hippo pathway restricts cellular growth by preventing nuclear accumulation of the Yes-associated protein (YAP) transcriptional co-activator. YAP expression is elevated in CRCs suggesting that, like Wnt/ß-catenin signaling, the Hippo pathway may contribute to colorectal carcinogenesis.
This paper was published online in The Journal of Biological Chemistry and is free to access.
Drug Transport Gene May Explain Why Ovarian Cancer Patients React Differently to ChemotherapyNews
A gene which produces a protein that transports drugs in and out of cells may explain why some women treated with chemo have serious side effects.READ MORE
The Butterfly Evolutionary Tree Is Now Bigger and BetterNews
The latest tree uses 35 times more genetic data and has three times as many taxa.READ MORE
DETECTR Sniffs Out DNA Signals Using CRISPR-Cas9's CousinNews
A new technology allows amplification and detection of genomic snippets present in a sample, using the enzyme Cas12.READ MORE