Unexpected Role for Epigenetic Enzymes in Cancer
News Dec 06, 2016
To better understand how cancer initiates and spreads, Yale associate professor of pathology Qin Yan turned to the field of epigenetics, which examines changes in the expression of genes and proteins that do not affect the underlying genetic codes.
In a Yale-led study, Yan and his co-authors focused on a family of enzymes — known as KDM5 — that had been shown in previous studies to be involved in cancer cell growth and spreading.
First author Lauren Blair, an associate research scientist, conducted biochemical studies with Baker’s yeast as the model system, and identified an unexpected role of these enzymes in the process by which genetic messages are interpreted by yeast cells. Further studies showed that the enzymes’ role as regulators of this process is also important for human tumor cells to grow and spread. The finding could lead to a therapy that inhibits the enzyme, and tumor growth, in cancer patients.
Story from Yale University. Original piece written by Ziba Kashef. Please note: The content above may have been edited to ensure it is in keeping with Technology Networks’ style and length guidelines.
Blair, L. P., Liu, Z., Labitigan, R. L. D., Wu, L., Zheng, D., Xia, Z., … Yan, Q. (2016). KDM5 lysine demethylases are involved in maintenance of 3’UTR length. Science Advances, 2(11),. doi:10.1126/sciadv.1501662
Genomics Researchers Showcase their Applications of Droplet Digital PCR at ASHG 2017 Annual MeetingNews
The sensitivity and reliability of Droplet Digital PCR will be showcased in over a dozen presentations at the American Society of Human Genetics (ASHG) 2017 Annual Meeting.READ MORE
BC Platforms Announces Collaborations in Multiple Sclerosis ResearchNews
Company's technology and research platforms used to better understand genetic basis of MS.READ MORE
QIAGEN and CENTOGENE to Collaborate in Bioinformatics for Genetic DiseasesNews
Aiding the analysis of hereditary disorders by integrating genomic and clinical databases.READ MORE
Comments | 0 ADD COMMENT
Annual Conference on Antimicrobials and Drug Resistance
Sep 24 - Sep 25, 2018