Unexpected Role for Epigenetic Enzymes in Cancer
News Dec 06, 2016
To better understand how cancer initiates and spreads, Yale associate professor of pathology Qin Yan turned to the field of epigenetics, which examines changes in the expression of genes and proteins that do not affect the underlying genetic codes.
In a Yale-led study, Yan and his co-authors focused on a family of enzymes — known as KDM5 — that had been shown in previous studies to be involved in cancer cell growth and spreading.
First author Lauren Blair, an associate research scientist, conducted biochemical studies with Baker’s yeast as the model system, and identified an unexpected role of these enzymes in the process by which genetic messages are interpreted by yeast cells. Further studies showed that the enzymes’ role as regulators of this process is also important for human tumor cells to grow and spread. The finding could lead to a therapy that inhibits the enzyme, and tumor growth, in cancer patients.
Story from Yale University. Original piece written by Ziba Kashef. Please note: The content above may have been edited to ensure it is in keeping with Technology Networks’ style and length guidelines.
Blair, L. P., Liu, Z., Labitigan, R. L. D., Wu, L., Zheng, D., Xia, Z., … Yan, Q. (2016). KDM5 lysine demethylases are involved in maintenance of 3’UTR length. Science Advances, 2(11),. doi:10.1126/sciadv.1501662
RNA That Helps Grow Blood Vessels Could Aid Heart Disease ResearchNews
STEEL, a noncoding RNA, acts on genes to stimulate produce of blood vessels, a finding which could advance efforts to combat heart disease.READ MORE
1200 Year Old DNA Helps Find Living Descendants of Indigenous Taíno AmericansNews
A genomic study has found that he Taíno, a population of early indigenous Americans, have living descendants, debunking theorists who had claimed they were extinct.READ MORE
Duplicate Genes Offer a Explanation for Differences Between the SexesNews
A study in flies has identified the process by duplicating a gene can help resolve genetic sexual conflict.READ MORE