University of Washington Purchases arrayWoRx® Biochip Reader
News Oct 07, 2005
Applied Precision, LLC has announced that the University of Washington (UW) has purchased its arrayWoRx® Biochip Reader to enhance its genomics research efforts.
Researchers from the UW School of Medicine's Department of Genome Sciences worked closely with Applied Precision to conduct a thorough evaluation of the system for use in array comparative genome hybridization (arrayCGH) scanning.
According to Researchers, the arrayWoRxe Biochip Reader was selected because it generates highly accurate and repeatable quantitative data, as well as provides application flexibility necessary for arrayCGH scanning.
“ArrayCGH is a new screening tool for genetic research that provides high-resolution genome analysis technology to detect copy number variation, including segmented chromosomal deletions and duplications without actually looking at chromosomes,” said Evan Eichler, Associate Professor at the University of Washington's Department of Genome Sciences.
“After an intense evaluation of different platforms, Applied Precision's arrayWoRxe Biochip Reader was found to provide the most reproducible results and will play a key role in the laboratory's arrayCGH scanning efforts.”
“The accuracy, speed and application flexibility of the arrayWoRxe microarray scanning system will enable the university to harness the significant potential arrayCGH scanning holds for genomics research and discovery efforts.”
“ArrayCGH scanning is a powerful example of how the arrayWoRxe Biochip Reader is enabling new microarray scanning applications - now being adopted by leading research, clinical and diagnostic laboratories,” said Brent Navran, Life Sciences Product Line Manager for Applied Precision.
“Genome-wide screening for chromosomal imbalances is already providing a wealth of new data on previously unrecognized tumor-specific genomic alterations.”
“Conducting such CGH analysis on microarrays using defined DNA probes with the arrayWoRxe Biochip Reader significantly enhances both data accuracy and speed of collection.”
“We look forward to future collaborations and to supporting the valuable, leading-edge scientific research conducted by the University of Washington.”
Applied Precision's arrayWoRxe Biochip Reader is designed to offer superior application flexibility.
The system achieves an unmatched 3.25 micron per pixel image resolution for life science applications, due to the integration of leading-edge and proprietary mechanical and optical systems.
Full-spectrum white light-based four color imaging technology, with a range of 350nm to 750nm, improves photon collection and also contributes to the lowest ratio coefficient of variation (CVr) in the industry, so that usable data is acquired and faulty data eliminated.
The system's intuitive automated preset scanning software, combined with simultaneous scanning and analysis technology, simplifies and speeds the imaging and analysis process.
In addition, changing wavelengths simply requires using different optical filters, while the standard model includes filter sets that support up to 89 low-cost fluorescent dies-contributing to both robust application flexibility and low cost of ownership.
As genome editing technologies advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. However, challenges need to be addressed before potential treatments can be widely used in patients. To tackle these challenges, the National Institutes of Health has launched the Somatic Cell Genome Editing program, which has awarded multiple grants including more than $3.6 million to assess the safety of genome editing in human cells and tissues.