We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
What's in a GENRE?
News

What's in a GENRE?

What's in a GENRE?
News

What's in a GENRE?

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "What's in a GENRE?"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

A new study from Jason Papin’s group at the University of Virginia’s Department of Biomedical Engineering published in Nature Communications describes the first genome-scale reconstruction (GENRE) of rat (iRno) and human (iHsa) metabolism. Their GENRE’s comprehensively map the metabolic differences between the species, such as their vitamin C and bile acid synthesis pathways.

Given that rats are used as human surrogate models to test hepatotoxicity in pre-clinical testing in pharma, understanding and predicting species-specific differences and similarities in drug metabolism between them and humans has cost, time and health benefits for drug development.

The authors integrated toxicogenomics microarray data from rat and human hepatocytes into their GENRE models as transcriptionally inferred metabolic biomarker responses (TIMBR).

They then ‘validated their predictions for xanthine derivatives with new experimental data and literature-based evidence delineating metabolite biomarkers unique to humans.’ (Blais et al. 2017)

Their study provides a systems-level overview of species-specific differences between rat and human metabolism captured with their in silico GENREs. This work highlights both the genomic similarities between humans and rats, but also reveals the metabolic pathway differences between the species which have been overlooked. This extra knowledge will aid preclinical development.

Written by Adam Tozer, Ph.D, Science Writer for www.TechnologyNetworks.com

Reference:

Blais, E.M., Rawls, K.D., Dougherty, B.V., Li, Z.I., Kolling, G.L., Ye, P., Wallqvist, A. and Papin, J.A. (2017) ‘Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions’, Nature Communications, 8, p. 14250. doi: 10.1038/ncomms14250.


Advertisement