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Why CRISPR Doesn't Always Work

News   Jul 11, 2018 | Original Press Release from the University of Illinois at Chicago

 
Why CRISPR Doesn't Always Work

UIC researchers show persistent Cas9 binding to a double strand break causes CRISPR genome editing to fail about 15 percent of the time. When RNA polymerases collide with Cas9 from one direction (template orientation), they can dislodge Cas9 and increase genome editing efficiency. Credit: Ryan Clarke, et al)

 
 
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