Latest Posters

There is more to DNA than A, C, G and T, epigenetics plays a causal role in cell fate, aging and disease development. Genetic and methylation data together on the same read allow us to get a more complete picture of genome biology. Constrained to measuring four states of information, existing NGS- based technologies sacrifice genetic for methylation calling.

This poster demonstrates how a novel, precise and highly controlled iPSC reprogramming technology overcomes these limitations and enables the generation of mature cell types and isogenic models of neurodegenerative disease.

Increased demand has led to an overwhelming volume of LC-MS/MS data and a requirement for analytical software that can simplify its interpretation. This poster highlights a new, comprehensive software solution capable of eliminating the otherwise overwhelming efforts of manual data interpretation.

Formaldehyde fixed & paraffin-embedded (FFPE) tissue blocks are one of the most commonly used and archived sample types. However, some preservation approaches can result in the degradation of RNA and hinder transcriptome profiling .

Patient-derived induced pluripotent stem cells (iPSCs) enable generation of in vitro models that can recapitulate human disease phenotypes. However, conventional human iPSC differentiation protocols are often lengthy, inconsistent and difficult to scale.

Traditionally, there has been a compromise between performance and sustainability.

Researchers looking to answer complex biological questions often require increased statistical power, larger studies and deeper sequencing methods.

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function.

The growing use of RNA-based vaccines and therapies has focused much attention and effort on developing conditions for maximizing the yield and efficiency of the in vitro transcription (IVT) reactions used to produce mRNA. IVT procedures involve the biosynthesis of RNA from a linear DNA template containing an appropriate transcription promoter. But how do different buffer conditions and nucleotide concentrations impact the IVT reaction?

Membrane proteins are a notoriously difficult class of proteins to express, purify and characterize. Expression levels of membrane proteins in mammalian expression systems, the preferred system to generate native-like post-translational modifications, are often so low that yields are unsuitable for the intended downstream uses.