Latest Posters
Poster
Target length effect on sensitivity and specificity of oligonucleotide microarrays: Advantages of a modified PCR based labelling method over the dendrimer technology.
Several methods have been developed for target labelling to enable DNA microarray quantification without taking careful consideration for target length effect. This report highlights the importance of choosing the optimum target length that would ensure specificity without compromising sensitivity of the assay. It also shows the advantages of using the modified PCR method over other methods in generating labelled amplicons of the desired lengths to maximize hybridization efficiency.
Poster
Visualizing the Dynamic Epigenome
A method is presented to visualize genome-wide information from epigenetic data. It is capable to integrate additional information. Applied to mouse data consisting of H3K4, H3K27, and H3K9 trimethylation for 3 different celltypes, the dynamic behavior and interplay was investigated.
Poster
miREC: A database of miRNAs involved in endometrial cancer
The miREC database integrates public data about miRNAs and their target genes involved in the development of EAC in human, collected from recent literature. In future versions the database will be complemented with information derived by analyzing our in-house data and new published data by other researchers. The miREC database is the first database that focuses on integrating all available information about genes and miRNAs involved in endometrial cancer.
Poster
MicroRNA expression in normal and malignant prostate tissues
In this study the aim was to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. Nine miRNAs were found to be differentially expressed and they could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature, showing an accuracy of 85%.
Poster
Quercetin Accumulation is Associated with Drought Resistance in White Clover
White clover is an important pasture legume, but growth is often strongly reduced under summer drought. Abiotic stress is mediated by the induced production of flavonoids. At the individual genotype level, increased flavonol (quercetin) accumulation in response to water deficit stress is positively associated to retaining higher levels of dry matter production.
Poster
Novel Serological Assay Using HIgh-Throughput Chromogenic Microarray Technology for Screening SPF Non-human Primates
Routine surveillance programs to detect microbial agents in non-human primate colonies are critical to maintaining colony health and safety, as well as research integrity. Serological testing is a crucial element of maintaining colony health, but current methods rely on slow, expensive, and low-throughput ELISA-based serological assays. Here we describe the development of a sensitive, specific, robust, and easily automated method for colony health screening programs.
Poster
Drought Induced Increase in Quercetin Glycosides is Associated with Drought Resistance in a Novel White Clover Population
White clover is an important forage legume in temperate pastures, but does not have sufficient resistance against drought stress. Quercetin is a flavonol conferring plant sunscreen and anti-oxidant properties under UV-B stress with a trade-off of reduced biomass. An F1 full-sib cross between stress tolerant and stress sensitive white clover genotypes showed the ability to increase Q accumulation associated to maintenance of dry matter yield under a near wilting drought.
Poster
Repurposing Drugs for the Treatment of Multi-Drug Resistant Breast Cance
In this study, the Johns Hopkins Clinical Compound Library, containing approximately 1,500 FDA and foreign-approved clinical compounds, was used to screen a multi-drug resistant, triple negative breast cancer cell line for drug sensitivity.
Poster
Genome sequenicng and analysis of the emerging pathogen Corynebacterium ulcerans
Sequencing of two C. ulcerans isolates and identification of a noval putative virulence factor
Poster
A high-throughput colony formation assay for profiling novel compounds and RNAi reagents using the Acumen® eX3
Cell colony formation assays measure a cell's ability to grow unattached to a surface and have applications in a range of areas including hematopoietic stem cell research, cell transformation studies and the prediction of responses of tumors to chemotherapeutic agents. The results of this study demonstrated that Acumen eX3 can be used as a high-throughput platform for investigation of effects of test compounds and RNAi reagents on cell colony formation.
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