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We describe the natural history of a cohort of 12 patients with confirmed partial RAG1/2 mutations and autoimmunity at a young age. We were seeking the link between viral infections and autoimmunity and tested candidate biomarkers that may reflect the underlying RAG1/2 protein deficiency.

A web tool that performs complete crRNA specificity checking is introduced. In addition, we evaluated positional off-targeting of the CRISPR system.

In this study, the role of miRNAs has been assessed in a large cohort of pancreatic cancer.

Our objective is to validate diagnostic services using Oxford Nanopore’s Minion in the first instance and to evaluate the cost and performance compared to existing sequencing technology in areas such as tumour DNA sequencing (and circulating tumour DNA), virology, microbiology, genetics and HLA-typing.

The method allows for automated determination of total fat content and quantitative analysis of saturated and unsaturated cis- and trans- fatty acids of different chocolate products.

Here, we focus on quantification, sizing, and sensitivity of both D5000 ScreenTape assays.

We aim to better understand the parameters affecting CRISPR-Cas9 editing efficiency for functional gene knockout utilized synthetic crRNAs and tracrRNA.

To better understand the dietary practices of emerging adults, and college students more specifically, it is necessary to use effective measurement techniques. The purpose of this critique is to compare dietary intake measures used in research assessing dietary practices among college students.

The goal of this pilot study was to exploit NGS technology with a view to shedding new light on the genome of cells used in the MLA, as well as the changes induced as a result of the exposure to mutagens.

Our results indicate that MS modifications are required for experiments with co-electroporation of Cas9 mRNA and synthetic gRNA, yet have no impact on editing efficiency when delivered with lipid-based transfection reagents.