Automated Genomic DNA QC Ensures High Quality Data from Downstream Workflows
Poster Nov 05, 2012
Arunkumar Padmanaban, Ruediger Salowsky, Delphine Rabiller and Donna McDade Walker
The success of several genomics study depends primarily on the quality of starting material, which in most cases is the genomic DNA. The quality and quantity of the extracted genomic DNA affects the downstream applications like microarray studies, library constructions and gene expression studies. Since, these are expensive and time consuming applications the QC of the genomic DNA has become a mandatory at several stages of the experiment. The integrity of genomic DNA was traditionally studied using Agarose gel, which is more manual, cumbersome and involves exposure to hazardous chemicals like ethidium bromide.
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In summary, ISG15 expression levels are crucial for trophoblast morphology and function (migration/invasion). By blocking trophoblast invasion, reduced ISG15 levels could contribute to impaired spiral artery transformation that reduces utero-placental blood flow in preeclampsia. Thus, agents inducing ISG15 expression are likely to be therapeutic in preeclampsia.
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