Functional Proteomic Signatures of the Ubiquitin/Proteasome Pathway

We present preliminary findings on the application of of a new surface library, SeraFILE™, to the functional characterization of the Ubiquitin/Proteasome pathway. Important results are: markedly contrasted signatures of matched cancer to normal adjacent tissue, differential pools of proteasome regions and regulatory factors, altered catalytic rates, evidence of conformational isoforms resistant to small molecule inhibitors, and evidence of soluble regulatory factors.