Functional Proteomic Signatures of the Ubiquitin/Proteasome Pathway
Poster Apr 02, 2007
We present preliminary findings on the application of of a new surface library, SeraFILE™, to the functional characterization of the Ubiquitin/Proteasome pathway. Important results are: markedly contrasted signatures of matched cancer to normal adjacent tissue, differential pools of proteasome regions and regulatory factors, altered catalytic rates, evidence of conformational isoforms resistant to small molecule inhibitors, and evidence of soluble regulatory factors.
Despite the developments in conventional PCR, the complexity of multiplex Real Time PCR is still limited due to the lack of sufficient detection channels. To achieve high-end multiplexing capacity on standard Real Time PCR machines, Anapa Biotech has developed the MeltPlex® technology (see box on right).READ MORE