Hypothesis of an Existence of a Reverse Pathway (Rp) which Passes Genetic Information from Polypeptide Antigens to Ig Genes in B-Lymphocytes
Poster Sep 23, 2013
Victor J. Alexander
Current Clonal Selection Theory fails to adequately explain the presence of a “hyper mutation” particularly in 3 CDR sections of a V part of Ig genes, which are responsible for recognition and binding of antigens with a high affinity, the degree of wastefulness of random rearrangements of Ig genes in B- lymphocytes and a standard formation of four special recognition palindromic sequences after the1st V-D-J rearrangement.
The precision of the process allows for a hypothesis of an existence of a Reverse Pathway(RP) in B-lymphocytes which passes the exact genetic information from polypeptide antigens back to DNA, permitting for versatility and quick reaction in B-lymphocytes in response to foreign antigens.
The discovery of such a pathway will, undoubtedly, challenge the current Clonal Selection Theory of Immunology as well as the (current) Central Dogma of Molecular Biology which has established the DNA<=>RNA=>Protein pathway of genetic information. It is our hope that our pioneering Reverse Pathway Research Project will show that the genetic information can follow by both directions: DNA<=>RNA<=>Protein.
The discovery of such a reverse pathway will allow for a new, more effective and affordable treatment methods for curing many of the immune related diseases as well as cancer.
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