Hypothesis of an Existence of a Reverse Pathway (Rp) which Passes Genetic Information from Polypeptide Antigens to Ig Genes in B-Lymphocytes
Poster Sep 23, 2013
Victor J. Alexander
Current Clonal Selection Theory fails to adequately explain the presence of a “hyper mutation” particularly in 3 CDR sections of a V part of Ig genes, which are responsible for recognition and binding of antigens with a high affinity, the degree of wastefulness of random rearrangements of Ig genes in B- lymphocytes and a standard formation of four special recognition palindromic sequences after the1st V-D-J rearrangement.
The precision of the process allows for a hypothesis of an existence of a Reverse Pathway(RP) in B-lymphocytes which passes the exact genetic information from polypeptide antigens back to DNA, permitting for versatility and quick reaction in B-lymphocytes in response to foreign antigens.
The discovery of such a pathway will, undoubtedly, challenge the current Clonal Selection Theory of Immunology as well as the (current) Central Dogma of Molecular Biology which has established the DNA<=>RNA=>Protein pathway of genetic information. It is our hope that our pioneering Reverse Pathway Research Project will show that the genetic information can follow by both directions: DNA<=>RNA<=>Protein.
The discovery of such a reverse pathway will allow for a new, more effective and affordable treatment methods for curing many of the immune related diseases as well as cancer.
Cerebral Malaria Insights: Pathogenesis, Host Parasite Interactions including Host ResistancePoster
Cerebral malaria is a dreadful disease transmitted by mosquito. The major preventive approach is focused more in vector control than development of anti-malarial drug. The purpose of this presentation is to analyze different aspects of disease manifestations including clinical symptoms and pathogenesis in the context of mosquito borne infections in different geographical regions of the world.READ MORE
Amoebic Meningoencephalitis: Etiology, Infection and PreventionPoster
The presentation covers the different types of organisms that can cause amoebic meningioencephalitis. The two main types focused on are primary amoebic meningioencephalitis and granulomatous amoebic meningioencephalitis. The method of transmission and target hosts are vastly different. Prevention of these diseases is imperfect at best, as complete avoidance is the only way to not contract the disease.READ MORE
Depressive Symptoms Related to Biological Markers of Immune Functioning among Young People with HIVPoster
Youth living with HIV (YLWH) are at risk for depression. This study aimed to identify trends in depressive symptoms for YLWH in a specialty-care clinic and follow up clinical treatment procedures.READ MORE