Identification and Characterization of Strain Specific Drug Target by Subtractive Genome Analysis of Methicillin Resistance Staphylococcus aureus
Poster Feb 20, 2013
Kiran Saeed and Reaz Uddin
In the present study, the idea was to utilize the strain specific available genome or proteome by using ‘subtractive genomics approach’ which helped in the identification and characterization of strain specific drug targets along with comparative analysis within two of the Methicillin resistance Staphylococcus aureus (MRSA) strains i.e., MRSA398 and MRSA252.The protocol involved various bioinformatics’ tools and databases like similarity search between pathogen and host, essentiality study using the database of essential genes, metabolic functional association study using Kyoto Encyclopedia of Genes and Genomes Database (KEGG), cellular membrane localization analysis, drug bank database.
Performance of the D5000 and High Sensitivity D5000 ScreenTape Assays for the 4200 TapeStation SystemPoster
Here, we focus on quantification, sizing, and sensitivity of both D5000 ScreenTape assays.READ MORE
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE