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Genomics Research

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Inhibition of DNA methylation does not overcome docetaxel resistance in human breast cancer cells

Poster

Published: September 25, 2009

Inhibition of DNA methylation does not overcome docetaxel resistance in human breast cancer cells content piece image

DNA mehtylation can lead to chemotherapy resistance in cancer. The aim of this study was to investigate the role of DNA methylation in docetaxel-resistant human breast cancer cells. Whereas the DNA methylation machinery is altered in docetaxel-resistant human breast cancer cells compared to docetaxel-sensitive human breast cancer cells, resistance to docetaxel could not be reversed using the DNA methylation inhibitor decitabine.