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Measuring Genetics and Epigenetics at Single-Base Resolution

Credit: iStock

Current NGS-based technologies only uncover information from the four genetic bases, overlooking the detail that epigenetic modifications give about gene expression.

Crucial distinctions between methylcytosine (5mC) and hydroxymethylcytosine (5hmC) modifications add complexity to DNA methylation dynamics. Hence, the integration of genetic and methylation data presents a unique opportunity to measure these cytosine modifications against gene expression. 

This poster highlights a cutting-edge sequencing technology which can simultaneously resolve all four genetic bases alongside cytosine modification status. 

Download this poster to explore:

  • How 6-base sequencing works
  • Insights into chromatin accessibility and enhancer states 
  • The potential of DNA-encoded epigenetic modifications in predicting gene expression 
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