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Genomics Research

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Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes

Poster

Published: October 14, 2008

| Last Updated: October 22, 2008

Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes content piece image

A role of mismatch repair (MMR) in modulating colorectal cancer (CRC) was assessed by genotyping single nucleotide polymorphisms in five MMR genes in hospital-based case- control study. The TAG haplotype in hMSH6 (-556G>T-Ex1-145G>-IVS4-101G>C) decreased a risk of CRC and the GGG haplotype increased a risk of rectal cancer. Although no significant association was found for individual MMR polymorphisms, the hMSH6 haplotypes may modulate the risk of CRC in this population.