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Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes
Poster

Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes

Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes
Poster

Modulation of sporadic colorectal cancer risk by polymorphisms and haplotypes of mismatch repair genes

A role of mismatch repair (MMR) in modulating colorectal cancer (CRC) was assessed by genotyping single nucleotide polymorphisms in five MMR genes in hospital-based case- control study. The TAG haplotype in hMSH6 (-556G>T-Ex1-145G>-IVS4-101G>C) decreased a risk of CRC and the GGG haplotype increased a risk of rectal cancer. Although no significant association was found for individual MMR polymorphisms, the hMSH6 haplotypes may modulate the risk of CRC in this population.
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