Over-representation of Proteins Identified as Disease Biomarkers and their Relation to Post-Mortem Events
Poster Sep 17, 2013
B. Orback, K. Kultima, M. Borén, M. Söderquist and K. Sköld
This poster reports a remarkable overlap between proteins commonly identified as changing in 2D-GE proteomic studies and those found to change post-mortem. Proteins with one or more phosphorylation sites are of particular interest since they appear to be overrepresented in this group.
The approach detailed may help differentiate true biomarkers from those proteins found in any situation where cells are under stress.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE