Prediction of Genes with U12-Dependent Introns in the Human Genome

Abstract
We enhanced the gene prediction program GeneID with a framework for detecting U12-dependent introns without appreciable loss in gene prediction sensitivity or specificity. We present statistics on the performance of the U12-enhanced GeneID on a test set of known U12-intron-possessing genes as well as results for scans of both the ENCODE regions and the entire human genome.