Simultaneous RT-qPCR Measurement of 1718 Long Non-Coding RNAs
Poster Sep 13, 2012
Pieter Mestdagh, Barbara D’haene, Jan Hellemans and Jo Vandesompele
Currently, expression and function of lncRNAs during human disease and development is largely unexplored. Few platforms are available that allow sensitive and specific high-throughput lncRNA expression profiling.
Study concludes, among other things, that lncRNA expression profiling of 60 cancer cell lines representing 9 different tumour entities reveals cancer-specific lncRNA expression profiles.
Inhibition of The Auto-inflammation Suppressor Protein ISG15 Triggers Preeclampsia by Blocking Trophoblast Migration and InvasionPoster
In summary, ISG15 expression levels are crucial for trophoblast morphology and function (migration/invasion). By blocking trophoblast invasion, reduced ISG15 levels could contribute to impaired spiral artery transformation that reduces utero-placental blood flow in preeclampsia. Thus, agents inducing ISG15 expression are likely to be therapeutic in preeclampsia.
An Emerging Phenotype of Partial RAG 1/2 Deficiency Among Young Children with Autoimmunity and Viral InfectionsPoster
We describe the natural history of a cohort of 12 patients with confirmed partial RAG1/2 mutations and autoimmunity at a young age. We were seeking the link between viral infections and autoimmunity and tested candidate biomarkers that may reflect the underlying RAG1/2 protein deficiency.READ MORE
Severe Combined Immunodeficiency (SCID) caused by thymic aplasia due to a mutation in TBX1Poster
We report one of the first cases of TBX1 haploinsufficiency causing complete thymic aplasia and SCID.READ MORE