Affymetrix Announces ChIP-on-Chip Array Product Line
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Affymetrix Inc. has announced the launch of nine tiling array products for five different organisms, further expanding the industry's broadest selection of whole-genome microarrays.
Affymetrix claims that, researchers in any laboratory can use the GeneChip® tiling arrays to map sites of DNA-protein interaction in chromatin immunoprecipitation ChIP-on-chip experiments, discover new RNA transcripts or investigate global epigenomic changes like methylation or acetylation.
Affymetrix tiling arrays are designed to deliver an unbiased view of entire genomes, enabling scientists to look beyond the known protein-coding gene sequences and thoroughly study gene structure, function and regulation.
"We are extremely pleased with the performance of the GeneChip tiling arrays for mapping transcription factor binding sites by ChIP-on-chip," said Myles Brown, M.D., associate professor of Medicine, Harvard Medical School and participant in Affymetrix' Tiling Array Early Access Program.
"These arrays have allowed us to comprehensively explore the non-repetitive regions of the entire human genome."
"This unbiased approach is already leading us to important new insights into the gene regulatory networks controlled by steroid hormones and their receptors."
Thomas R. Gingeras, Ph.D., vice president of biological science, and his team at Affymetrix Research Laboratories have used the tiling arrays to uncover broad transcriptional activity in large regions of the genome that were once considered "junk" DNA.
"Affymetrix tiling array technology is revealing a very important and unappreciated genetic realm that is challenging fundamental concepts of biology," said Gingeras.
"Using these arrays, we have been able to discover novel non-coding RNA transcripts and map the sites of DNA-protein interactions."
