AnaSpec Releases Four new Phosphospecific Anti-Tau Antibodies
Product News Nov 24, 2008
AnaSpec announces the release of four more phosphospecific anti-Tau antibodies. This represents the industry’s largest collection of anti-Tau antibodies - 17 phosphospecific and 9 non-phosphospecific antibodies, according to AnaSpec.
AnaSpec’s expertise in phosphopeptide synthesis combined with affinity purification has resulted in the production of an anti-Tau to phosphoserine at position 235 (cat# 55315) clearly delineated from one at phosphoserine position 238 (cat# 55323). AnaSpec’s phosphospecific antibodies do not cross-react with each other.
Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization. In adult human brain, 6 isoforms, ranging between 352 and 441 amino acids in length, are produced as a result of alternative RNA splicing. The expression of Tau isoforms is developmentally regulated, as only the smallest Tau polypeptide is expressed in the fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer’s disease.