Dionex Nucleic Acid Therapeutics Application Notebooks

Dionex announces the release of two applications notebooks in PDF format: the Protein and Antibody Therapeutics Applications Notebook and the Nucleic Acid Therapeutics.

The Protein and Anbtibody Therapeutics Applications Notebook compiles solutions for the development of protein and monoclonal antibody biopharmaceuticals, including charge and heterogeneity analysis, high throughput and automation, and peptide mapping.

The notebook demonstrates the use of Dionex HPLC systems for biomolecules, combined with an outstanding array of column innovations, in providing high-resolution purity analysis and protein characterization.

The Nucleic Acid Therapeutics Applications Notebook compiles solutions for the rapidly expanding field of nucleic acid therapeutics, including the analysis of phosphorothioate oligonucleotides; analysis of single-stranded and double-stranded RNA for therapeutic applications; coupling of anion-exchange HPLC to ESI-MS using automated desalting with a titanium-based LC system; AX-HPLC-ESI/MS of derivatized oligonucleotides; preparative and analytical separations of nucleic acid diastereoisomers; separation and analysis of RNA containing aberrant linkage isomers; analysis of nucleoside mono-, di-, and triphosphates; and useful information for new method development.