Epigentek Releases Its Next Low-Cost, High-Throughput Sonication Devices for DNA and Chromatin Shearing

New product introduces additional technological advantages including better optimized application protocols, isothermal processing, and redesigned circuitry. These enhancements make the EpiSonic(TM) specifically suitable for next generation DNA sequencing.

The ever-increasing importance of next-gen sequencing and the reduction in sequencing costs have spurred a demand for higher throughput and a more efficient library preparation process. Similarily, chromatin immunoprecipitation (ChIP) has played a prominent role in epigenetic studies and has also called for a reliable method of sample preparation.

The EpiSonic(TM) 1100’s Digitally Adaptive Sonocavitation(TM), or DAS(TM), technology provides a digital means to control shearing intensity with superb precision to achieve user-desired fragment sizes. The high throughput feature of the device is consistent so that samples placed in different positions are able to maintain equal sheared lengths between each other. Moreover, samples are sheared into reproducible sizes between the first run and the next run, creating predictable results and eliminating optimization time and labor.

The most appealing aspect of the device is the affordability, enabling every laboratory to have a reproducible and effective shearing instrument. With the high throughput capability to simultaneously shear 96 samples or more at a time, the cost per run has never been lower.