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Extensive Range of Bromodomain Protein Domains & Profiling Kits
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AMSBIO provides an extensive portfolio of bromodomains and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery.
Bromodomains (BRDs) are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
The ability of bromodomain regulators to alter chromatin status and control gene expression is important in the development of certain human cancers, adipogenesis, energy metabolism and inflammation.
Bromodomains are emerging as a new class of targets, alongside HATs and HDACs, which will be important in drug discovery. There are over 50 proteins containing one or more BRDs.
Better understanding of bromodomains will also lead to better design of epigenetically-directed therapeutics.
