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Genetix Confirms Bead-based Assay Capabilities for CellReporter System

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Genetix has confirmed that its CellReporter system now supports both cell- and bead-based assay formats. Users can screen cell-by-cell or bead-by-bead within a test population in order to produce quantitative data for a wide range of applications.

Typically used to quantify the amount of protein secreted by a cell line, bead-based assays are key to applications such as hybridoma screening, assessing production of antibodies, cytokines or hormone secretion. The homogeneous format of the bead-based assays used with CellReporter significantly simplifies the process compared to conventional approaches, as it involves only a single incubation step and eliminates the need for multiple wash steps.

Cell-based assays, including cell cycle analysis, cytotoxicity studies and monitoring protein translocation,  are used as biological models of physiological situations, for example when investigating the effect of drug candidates on a cancer cell model.

The CellReporter system enables scientists to increase throughput without compromising image or data quality. In addition, the accuracy of the quantitative data can be substantially improved compared to conventional approaches. Flexible image analysis software identifies and analyzes each object, such as the cell nucleus or bead. Users can optimize and standardize image interpretation for each assay and check data quality, for example to remove fluorescent debris that may compromise results.

Charles de Rohan, head of the Genetix Business Unit within Leica Microsystems, explained: “Data from cell- and bead-based assays are critical to a multitude of research, drug discovery and development projects. The CellReporter system now offers a truly multi-application platform that can support basic research projects as well as provide data essential in drug discovery and development workflows.”