Invitrogen Introduces Dynabeads® SCX for Proteomic Sample Preparation
Product News Feb 06, 2007
Invitrogen Corporation announces the availability of Dynabeads® SCX, the proteomic sample preparation product from Dynal.
Dynabeads® SCX are designed with an optimized surface for binding and fractionation of intricate protein and peptide mixtures. Using strong cationic exchange (SCX), these magnetic beads precisely separate proteomic samples based on isoelectric point and net charge differences, in preparation for downstream analyses such as mass spectrometry, HPLC or 1D/2D gel electrophoresis.
Dynabeads® SCX add further functionality to Dynal’s existing magnetic bead chromatography product line, which includes products for cation exchange (Dynabeads® WCX), anion exchange (Dynabeads® SAX) and hydrophobic capture (Dynabeads® RPC 18 and Dynabeads® RPC Protein).
Beads with different surface characteristics can be combined to isolate different fractions from the same sample, allowing for step-wise reduction of sample complexity.
“These versatile Dynabeads® products can be used to concentrate, prepare and desalt complex protein and peptide mixtures, making them particularly valuable for serum profiling in biomarker and drug discovery,” says Beate Rygg Johnsen, Business Area Manager at Dynal.
“The magnetic separation methodology is fast, reproducible, flexible and scalable, and can be automated on a wide variety of liquid handling platforms for both top-down and bottom-up approaches, offering an excellent alternative to chromatography columns, spin columns and pipette tip technologies.”