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Life Technologies Launches new in vivo siRNA Gene-Silencing Kits and Reagents


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Life Technologies Corporation has announced the introduction of Invivofectamine® 2.0 Reagent and Ambion® In Vivo siRNA – two new products that will enable researchers to perform efficient siRNA silencing (gene “knock-down”) experiments in small animal models.

Product tests by Life Technologies scientists produced effective targeted gene silencing lasting more than three weeks with a single application of Invivofectamine® 2.0 Reagent and the positive control Ambion® In Vivo siRNA. They also knocked down up to four genes simultaneously with a single application of four different siRNA molecules. The new reagents provide an alternative to the conventional use of knock-out mouse models, which can take nearly 10-months to develop.

Over the last decade, life science researchers have used siRNA (small interfering RNA) to elucidate the function of many genes, a key step in validating potential targets in the drug discovery process. However, the lack of robust tools on the market for in vivo experiments has been a barrier to greater use of this powerful technology.

“Invivofectamine® 2.0 Reagent and Ambion® In Vivo siRNA provide strong and sustained knockdown of in vivo protein expression in an easy-to-use kit,” said Charles Piazza, Head of Molecular Biology Reagents for Life Technologies. “These tools will accelerate the use of RNAi to efficiently study gene function in animal models.”

Sold as part of a 1ml starter kit or a 5ml kit, Invivofectamine® 2.0 Reagent and Ambion® In Vivo siRNA are synthetic, contain no components of viral origin, and show minimal to no toxicity after extensive initial studies.
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