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New Detection Cartridges Extend Applications of PARADIGM™ Platform

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Beckman Coulter, Inc. announces four new cartridges for the PARADIGM Detection Platform, the company’s user-configurable and upgradeable multimode reader. The new cartridges increase the total number of interchangeable detection choices to 14, extending platform utility and return on investment for PARADIGM customers.

The new options include two additional luminescence detection cartridges optimized for 96- and 384-well plate formats, a new detection cartridge for BRET2* (Bioluminescence Resonance Energy Transfer) live cell assays and a Rhodamine fluorescence cartridge for a selection of cyanine dyes.

Two of the four new detection cartridges expand the PARADIGM’s Glow Luminescence line with offerings specially designed for 96- and 384-well applications. These complement the existing Glow Luminescence Detection Cartridge optimized for the 1536-well plate format. The well-isolating design of each cartridge is optimized for a specific plate format to provide increased sensitivity with reduced cross talk.

The new Dual Luminescence Detection Cartridge is optimized for use with BRET2 live cell assays and includes predefined protocols and data analysis tools.  This cartridge is ideal for the study of protein-protein interactions.

The new Fluorescence Intensity Detection Cartridge delivers speed and high sensitivity in applications using Cy3 and equivalent Rhodamine fluorescent labels. This new cartridge expands Beckman Coulter’s detection menu for FRET (Fluorescence Resonance Energy Transfer) assays by reading Cy3 paired with Cy5 or Cy5.5 dyes, which are commonly used in genomics and proteomics research.