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Novel Agent for Reactive Metabolite Detection
Product News

Novel Agent for Reactive Metabolite Detection

Novel Agent for Reactive Metabolite Detection
Product News

Novel Agent for Reactive Metabolite Detection


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AnaSpec has announced the availability of QA-GSH, a quaternary ammonium glutathione analogue conjugating agent.

Bioactivation of drug candidates resulting in chemically reactive, electrophilic metabolites have always presented a major challenge to pharmaceutical companies. Moreover, the measurement of these metabolites has been hampered by the lack of an effective quantitative method. QA-GSH is a new tool for the detection of reactive metabolites.

Developed by Pfizer, this compound can provide semiquantitative assessment of the bioactivation potential in vitro for semiquantitative LC-MS/MS detection of reactive metabolite. The methodology is well suited for use in early drug discovery high throughput screening paradigms.

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