Phoenix S&T Announces Availability of the SureSpray™ AutoNano System

Phoenix S&T, Inc. has announces the availability of the automated SureSpray™ AutoNano System for nanoLC and direct-infusion mass spectrometry analysis of proteins and metabolites.

The AutoNano builds on the success of the non-clogging and robust spray of the polypropylene SureSpray™ nozzle technology to render nanospray mass spectrometry routine and high throughput.

“Nanospray mass spectrometry has become the work horse for proteomics because of its high sensitivity and low sample consumption, and is emerging as the desirable technique for high sensitivity detection of metabolites in body fluids. The AutoNano takes away a lot of the more difficult and variable aspects of nanospray mass spectrometry that demand a steep leaning curve.

For example, the constant clogging of the nanospray emitter and the unpredictable spray stoppages during a long LC run are virtually eliminated by the AutoNano. For researchers who survey a large number of samples without chromatographic separation, the speed of the AutoNano System is unsurpassed. Ten seconds per sample is possible,” says Sau Lan Staats, President of Phoenix S&T.

The SureSpray™ AutoNano System deploys a 16-nozzle chip for both nanoLC-MS and direct infusion-MS. The system robotically connects a capillary LC column to a nozzle in the chip and ensures undisrupted spray during the entire gradient chromatographic run with a patent-pending active spray control mechanism that regulates the electrostatic field for a stable spray.

For direct infusion experiments, the sample is sprayed directly from the reservoir behind the nozzle. Switching samples takes just 2 seconds. Sample loading is either by hand or with an optional robotic liquid dispensing system.