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SCIENION’s sciFLEXARRAYER Used for Cantilever Biosensor Production
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Research at the Bionanomechanics Lab, which is part of the Microelectronics Institute of Madrid, is intended to advance basic and applied knowledge in nanotechnology and its application in the biomedical field.
The Bionanomechanics Lab is using the sciFLEXARRAYER to immobilize thiolated single stranded DNA onto gold-coated silicon microcantilevers.
This produces a homogeneous self-assembled monolayer (SAM) on each cantilever. After incubating these cantilevers with complementary DNA sequences, hybridization results in a deflection (bending) of the cantilever that is in turn detected with an optonanomechanical read-out platform(SCALA).
Present research focuses on the detection of Mycobacterium tuberculosis. Plans for the utilization of the sciFLEXARRAYER for a range of applications, such as lung cancer detection or for the production of protein cantilevers, are underway.
Dr. Holger Eickhoff, CEO of SCIENION AG, states: “Nanomechanical biosensors show an ever-improving sensitivity limit for the label-free detection of biomolecules. The Bionanomechanics Lab is a frontline innovator in biosensing nanotechnologies and has been setting standards in this field. This is reflected by an impressive number of scientific articles in renowned high impact journals. We are very excited that our sciFLEXARRAYER technology is used to advance the cutting-edge research of the group and thus contributing to the development of the next generation nanomechanical biosensors.”
Dr. Montserrat Calleja, Head of Dept. Devices, Sensors and Biosensors, Bionanomechanics Lab, Microelectronics Institute of Madrid, comments: “The Scienion spotter provides the needed flexibility to address cantilever sensors of almost any size and design. This is a promising technology for the functionalization of microcantilevers as it is fast, versatile and suitable for large-scale integration. This technique suits the need of high throughput functionalization of arrays of nanomechanical systems as the inkjet head does not contact the surface of the fragile devices.”
Products based on developments at the Bionanomechanics Lab, such as the SCALA detection device and also upcoming label-free kits for DNA hybridization detection, are commercialized by Mecwins S.L., that holds license of three patents from the Bionanomechanics research.
