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SwitchGear Genomics Launches the Largest Collection of Transcription Factor Response Element Reporter Vectors

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SwitchGear Genomics, Inc. launched the LightSwitch Synthetic Response Element GoClone reporter constructs for understanding transcription factor activity in living cells. The new reporter collection of nearly 100 response element vectors represents the largest collection of synthetic response element reporter vectors on the market. The collection of synthetic response elements also complements the company’s genome-wide set of 18,000 endogenous human promoter reporter vectors.

The synthetic response element reporters contain repeated motifs of a transcription factor binding site cloned upstream of a minimal promoter and the company’s novel RenSP luciferase gene. These vectors are used in primary screening assays to understand how drug candidates may affect important biological pathways. The response element reporters can also be used as positive controls in biological pathway analysis.

“We are committed to providing the most comprehensive set of reporter assay content, and the LightSwitch Response Element Collection is an important part of that effort,” said Shelley Force Aldred, Ph.D., co-founder and President of SwitchGear Genomics, Inc.,“In addition to our genome-wide promoter and 3’UTR collections, controls, and luciferase assay reagents, we now offer the industry’s most extensive collection of synthetic response element reporters.” Aldred also remarked that the combination of the company’s synthetic reporters with its endogenous reporters provide pharmaceutical researchers with a powerful tool for primary and secondary screening applications.