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Twist Bioscience Launches cfDNA Library Preparation Kit for Liquid Biopsy Applications

A rack of blood samples.
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 Twist Bioscience Corporation (NASDAQ: TWST), launched the cfDNA Library Preparation Kit to enable liquid biopsy research.

Liquid biopsies have gained prominence in critical applications such as cancer screening, including multi-cancer early detection screening and monitoring for minimal residual disease (MRD). Liquid biopsy tests are designed to accurately identify tumor variants within circulating tumor DNA (ctDNA), which are often difficult to detect due to degraded or limited DNA presence. The Twist cfDNA Library Preparation Kit was purpose-built to maximize the number of unique cfDNA molecules that are captured in library preparation, for higher confidence in the accuracy and sensitivity of liquid biopsy tests.

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“Liquid biopsies can be life changing for patients, enabling earlier detection of cancer and profiling each patient’s unique tumor to inform personalized treatment plans,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “Even with advancements in the sensitivity of tests that have enabled the liquid biopsy field to expand, some tumor variants remain incredibly difficult for researchers to detect in the earlier stages of disease. With exceptional accuracy and sensitivity enabled by high conversion rates, the Twist cfDNA Library Preparation Kit can help push the limit of detection and detect lower frequency variants that can be missed by other on market library preparation solutions.”

The Twist cfDNA Library Preparation Kit adds to Twist’s growing portfolio of tools to support the research and development of liquid biopsy assays, which also includes the recently launched Twist cfDNA Pan-Cancer Reference Standard v2. The reference standards are a tool for researchers to use in the development and quality monitoring of clinically relevant variants for developing NGS-based assays. The updated reference standards include one of the industry-leading numbers of circulating tumor DNA (ctDNA) variants and clean background cfDNA for a significantly lower background error rate. The reference standards can be seamlessly integrated into Twist’s suite of target enrichment systems and custom capture panels.

Twist cfDNA Library Preparation Kit

The Twist cfDNA Library Preparation Kit can address challenges associated with library preparation from circulating cfDNA with reliable and robust performance from as little as 1ng sample input. It can detect even rare allele variants due to its high conversion rate. The cfDNA kit protocols minimize sample handling for a streamlined workflow and results delivered within two hours. The Twist cfDNA Library Preparation Kits are available in two configurations: the cfDNA Library Preparation Kit for whole genome sequencing (WGS) workflows and the Twist Library Preparation and Hyb Mix Kit for target enrichment.