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Modeling Neurodegenerative Diseases With Pre-Formed Fibrils
The research on neurodegenerative diseases like Alzheimer's disease (AD) and Parkinson's disease (PD) relies heavily on accurate disease models. Traditional transgenic or toxin-induced mouse models often fail to replicate the natural progression of these diseases. Pre-formed Fibrils (PFFs) offer a promising alternative by mimicking the seeding and propagation of pathogenic proteins, enabling more realistic in vivo and in vitro models for diagnosing, treating, and preventing neurodegenerative diseases.
Considering the pivotal role of Tau PFFs and Alpha-Synuclein PFFs in modeling AD and PD, Aneuro's Tau and Alpha-Synuclein PFFs products undergo rigorous quality control and validation to ensure the purity, homogeneity, and endotoxin levels of the monomers meet experimental requirements. The aggregation morphology and recruitment activity of the PFFs has been thoroughly verified through electron microscopy, ThT assays, and cellular-level experiments, ensuring their stability and reproducibility in AD and PD models.
As the brand of ACROBiosystems that focuses on neuroscience, Aneuro provides Tau-441 PFFs and Alpha-Synuclein PFFs supporting and accelerating the establishment of reliable neurodegenerative models.
