Biomarkers – Multimedia

This article highlights some of the wide range of applications which can be achieved using mass spectrometry.

In this talk, Matthias Nees discusses the development of cell culture model systems to recapitulate key aspects of cancer progression and to functionally validate biomarkers, target genes, and molecular signaling pathways.

The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).

A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.

We present results in rapid solution impedance spectroscopy to detect protein interactions (antibody-antigen) in human serum. Two different serum-antibody mixtures are measured in cuvettes, interfaced with screen-printed electrodes to determine whether the experimental setup can detect differences in composition.

A KNIME pipeline was developed to perform pre-processing of GC-MS data in an automated way and applied to a Inflammatory bowel diseases case study

Metabolomics represents an important tool for biomarker discovery in drug-resistant epilepsy and for the study of the pathophysiology of this disease.

Multiple sclerosis (MS) is a chronic disease characterized by a high level of heterogeneity. Metabolomics is an “-omics” approach with the potential to discover new biomarkers.

Apart from diagnostic devices, microfluidic devices are increasingly used to realise advance disease and organ-models, as illustrated by the blood-brain barrier chip and a blood vessel on a chip.

We first report on a magnetic surface coverage assay, in which ‘large’ (2.8 μm) magnetic beads have contact with ‘small’ (1.0 μm) immobilized magnetic beads via magnetic dipolar interaction to induce specific immunocomplex formation.