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Drug Kinetics – Multimedia

Assess Small Molecule Kinetics and Affinity in Just One Step - image
App Note / Case Study

Assess Small Molecule Kinetics and Affinity in Just One Step

This application note demonstrates how reliable kinetics and affinity can be obtained from single measurement data, increasing sample throughput and saving sample material.
Successful SPR Assays
App Note / Case Study

Determining Real-Time Kinetics and Affinity

This compendium serves as a user-friendly reference for assay design on both bio-layer interferometry (BLI) and surface plasmon resonance (SPR) systems.
Streamline Your Metabolite Identification and Clearance Analyses  content piece image
App Note / Case Study

Streamline Your Metabolite Identification and Clearance Analyses

Discover an automated solution for the consolidation and ranking of your metabolite structures. Explore a workflow that utilizes both EAD and CID data for the most confident characterization and streamlined data acquisition.
Revolutionary Binding Kinetics Analysis content piece image
How To Guide

Revolutionary Binding Kinetics Analysis

Conventional bioassays often require labeled detection reagents to provide a measurable readout. However, modifications to molecular structure and/or function can skew results, and non-specific binding of the labels themselves can lead to an unwanted background signal.
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App Note / Case Study

Identifying Metabolites With Confidence

Understanding the effects of in vitro drug metabolism is a key aspect of drug discovery and development. However, researchers must be able to make confident decisions quickly and easily.
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App Note / Case Study

Reach New Levels of Metabolite Characterization

Early ADME studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. Glucuronide conjugation is difficult to characterize using MS/MS alone, therefore fragmentation is also required to obtain structural information.
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Video

Design Intricacies and Decision Making Strategy for Drug Drug Interaction Studies

Conducting in vitro ADME drug-drug interaction (DDI) studies early on in the drug development process is more than simply a box checking exercise to satisfy regulatory requirements. The information provided by these studies provides a deeper understanding of the molecule to the drug developer helping to inform go or no-go decisions early on.
Video

Highlights of the In Vitro Sections of the Draft ICH Drug Interaction Studies Guideline and Comparison with Current Guidance

Hear expert Dr. Brian Ogilvie discuss the differences between current in vitro drug-drug interaction guidance from the relevant US FDA, EMA and PMDA guidance documents, and how to plan drug development strategies to meet the ICH M12 guideline.
RatPlasma
App Note / Case Study

Sensitive Analysis of a PROTAC Degrader in Rat Plasma

Proteolysis targeting chimera (PROTAC) degraders are used to treat drug-resistant targets via targeted protein degradation.
Filing an IND and Beyond: Development of CTD Section 2.6.4, Pharmacokinetics Written Summary content piece image
Video

Filing an IND and Beyond: Development of CTD Section 2.6.4, Pharmacokinetics Written Summary

This presentation was one of the keynote presentations from XenoTech's XenoTalks™ Seminar Series on the importance of ADME and Drug-Drug Interactions in drug development.
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